Our lab features cutting-edge research and groundbreaking publications that contribute significantly to the fields of anesthesiology and perioperative medicine. Our team of expert scientists collaborates to advance cardiac research. Through meticulous experimentation and peer-reviewed studies, we strive to enhance our understanding of cardiac function and develop innovative approaches to improve patient outcomes in heart failure.
Salavatian S, Kuwabara Y, Wong B, Fritz JR, Howard-Quijano K, Foreman RD, Armour JA, Ardell JL, Mahajan A. Spinal neuromodulation mitigates myocardial ischemia-induced sympathoexcitation by suppressing the intermediolateral nucleus hyperactivity and spinal neural synchrony. Frontiers in Neuroscience. 2023 Jun 2;17:1180294. Link
Howard-Quijano K, Yamaguchi T, Gao F, Kuwabara Y, Puig S, Lundquist E, Salavatian S, Taylor B, Mahajan A. Spinal Cord Stimulation reduces Ventricular Arrhythmias by attenuating reactive gliosis and activation of spinal interneurons. JACC Clin Electrophysiol. 2021 Aug 17:S2405-500X(21)00527-2. PMC34454884. Link
Kuwabara Y, Howard-Quijano K, Salavatian S, Yamaguchi T, Saba S, Mahajan A. Thoracic Dorsal Root Ganglion Stimulation Reduces Acute Myocardial Ischemia induced Ventricular Arrhythmias. Frontiers in Neuroscience.;17:27. Link
Howard-Quijano K, Takamiya T, Dale EA, Kipke J, Kubo Y, Grogan T, Afyouni A, Shivkumar K, Mahajan A. Spinal cord stimulation reduces ventricular arrhythmias during acute ischemia by attenuation of regional myocardial excitability. American Journal of Physiology-Heart and Circulatory Physiology. 2017 Aug 1;313(2):H421-31. Link
Howard-Quijano K, Kuwabara Y, Yamaguchi T, Roman K, Salavatian S, Taylor B, Mahajan A. GABAergic signaling during spinal cord stimulation reduces cardiac arrhythmias in a porcine model. Anesthesiology. 2023 Apr;138(4):372-87. Link
Yamaguchi T*, Salavatian S*, Kuwabara Y, Hellman A, Taylor BK, Howard-Quijano K, Mahajan A. Thoracic Dorsal Root Ganglion Application of Resiniferatoxin Reduces Myocardial Ischemia-Induced Ventricular Arrhythmias. Biomedicines. 2023 Oct 7;11(10):2720. Link
Salavatian S, Robbins EM, Kuwabara Y, Castagnola E, Cui XT, Mahajan A. Real-time in vivo thoracic spinal glutamate sensing during myocardial ischemia. American Journal of Physiology-Heart and Circulatory Physiology. 2023 Dec 1;325(6):H1304-17. Link
Omura Y*, Kipke JP*, Salavatian S*, Afyouni AS, Wooten C, Herkenham RF, Maoz U, Lashgari E, Dale EA, Howard-Quijano K, Mahajan A. Spinal Anesthesia Reduces Myocardial Ischemia-triggered Ventricular Arrhythmias by Suppressing Spinal Cord Neuronal Network Interactions in Pigs. Anesthesiology. 2021 Mar 1;134(3):405-420. PMC7878394. Link
Ho JK, Liakopoulos OJ, Crowley R, Yezbick AB, Sanchez E, Shivkumar K, Mahajan A. In vivo detection of myocardial ischemia in pigs using visible light spectroscopy. Anesth Analg. 2009 Apr;108(4):1185-92. doi: 10.1213/ane.0b013e3181951a65. PMID: 19299784. Link
Vaseghi M, Zhou W, Shi J, Ajijola OA, Hadaya J, Shivkumar K, Mahajan A. Sympathetic innervation of the anterior left ventricular wall by the right and left stellate ganglia. Heart Rhythm. 2012 Aug;9(8):1303-9. doi: 10.1016/j.hrthm.2012.03.052. Epub 2012 Mar 27. PMID: 22465457. Link
Vaseghi M, Yamakawa K, Sinha A, So EL, Zhou W, Ajijola OA, Lux RL, Laks M, Shivkumar K, Mahajan A. Modulation of regional dispersion of repolarization and T-peak to T-end interval by the right and left stellate ganglia. Am J Physiol Heart Circ Physiol. 2013 Oct 1;305(7):H1020-30. doi: 10.1152/ajpheart.00056.2013. Epub 2013 Jul 26. PMID: 23893168; PMCID: PMC3798747. Link
For the full list of Dr. Aman Mahajan’s research, visit PubMed.